Odborný program přednášky
Monday 29 August 2022 |
|
| 16.00 - 19.00 | Registration |
| 19.00 - 20.30 | Welcome cocktail - Campus |
Tuesday 30 August 2022 |
|
| 08.00 - 17.00 | Registration start + poster installation |
10.00 - 10.30 |
Opening ceremony |
| Chair: Kamil Kuča | |
10.30 - 11.15 |
Plenary lecture |
| Chair: Ondřej Soukup | |
| Organotypic and microphysiological human tissue models for translational toxicology and pharmacology Volker Lauschke (Stockholm, SWE) |
|
11.15 - 11.40 |
Flash posters I |
| Chair: Kamil Kuča | |
| FP01 |
Absence of Multidrug Resistance-Associated Protein 2 Increases the Plasma Concentrations of Bile Acids in Rats with Estrogen-Induced Cholestasis Fatemeh Alaei Faradonbeh (Hradec Králové, CZE) |
| FP02 |
Differences in the biological effects of bacterial and syntetic melanin Jiří Handl (Pardubice, CZE) |
| FP03 |
Human Precision-cut Intestinal Slices as a Model to Study Drug-mediated Induction of Intestinal ABCB1 and CYP3A4 Martin Huličiak (Hradec Králové, CZE) |
| FP04 |
Disruption of the aryl hydrocarbon receptor (AhR) signaling alters functions and production of surfactant in a human model of alveolar type II cells Martina Karasová (Brno, CZE) |
| FP05 |
Toxicity testing of new potential anthelmintics in parasitic nematode Haemonchus contortus and ovine liver Linh Thuy Nguyen (Hradec Králové, CZE) |
| 11.40 - 13.00 | Lunch and Exhibition |
13.00 - 14.05 |
Session 1 - Nanotoxicology |
| Chairs: Tomáš Roušar, Daniel Jun | |
| 13.00 - 13.45 keynote lecture |
One-dimensional nanomaterials and their (non)toxicity Jan Macák (Pardubice, CZE) |
| 13.45 - 14.05 |
Challenges in studying nanotoxicity in vitro Tomáš Roušar (Pardubice, CZE) |
| 14.05 - 14.30 | Coffee break |
14.30 - 16.10 |
Session 2 - Xenobiotics |
| Chairs: Mojmír Mach, Ondřej Soukup | |
| 14.30 - 14.50 |
The role of UDP-glycosyltransferases in xenobiotic-resistance Petra Matoušková (Hradec Králové, CZE) |
| 14.50 - 15.10 |
Targeting tacrine hepatotoxicity associated with the CYP biotransformation Ondřej Soukup (Hradec Králové, CZE) |
| 15.10 - 15.30 |
Gene regulation of major CYPs via xenobiotic nuclear receptors Petr Pávek (Hradec Králové, CZE) |
| 15.30 - 15.50 |
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease Jan Korábečný (Hradec Králové, CZE) |
| 15.50 - 16.10 |
The effect of potential carcinogen harman on selected Cytochrome P450 enzymes in rats Eva Klásková (Brno, CZE) |
16.10 - 17.30 |
Posters with coffee and tea |
| 18.30 - 21.30 | BBQ evening - Campus |
Wednesday 31 August 2022 |
|
08.30 - 09.15 |
Plenary lecture |
| Chair: Jan Korábečný | |
| A paradigm shift in understanding the mechanisms of anthracycline cardiotoxicity and opportunities for effective pharmacological cardioprotection Martin Štěrba (Hradec Králové, CZE) |
|
09.15 - 10.40 |
Session 3 - In vitro Toxicology |
| Chairs: Helena Kandárová, Kamil Kuča | |
| 09.15 - 10.00 keynote lecture |
International TraiN-SafeMD project: collaboration towards improved safety assessment of medical devices Helena Kanďárová (Bratislava, SVK) |
| 10.00 - 10.20 |
3R strategies in reproductive toxicology and biomedicine Iva Sovadinová (Brno, CZE) |
| 10.20 - 10.40 |
Manganese(III) porphyrins as anti- and pro-oxidants in high-molar-mass hyaluronan oxidative degradation Katarína Valachová (Bratislava, SVK) |
| 10.40 - 11.10 | Coffee break |
11.10 - 13.00 |
Session 4 - Nutrition and Evinronmental Toxicology |
| Chairs: Jan Vondráček, Jan Korábečný | |
| 11.10 - 11.40 keynote lecture |
Natural phenolic compounds and biological trace metals: double-edged sword Přemysl Mladěnka (Hradec Králové, CZE) |
| 11.40 - 12.00 |
Uncoventional environmental toxic ligands of the aryl hydrocarbon receptor (AhR) Jan Vondráček (Brno, CZE) |
| 12.00 - 12.20 |
Towards the high-throughput assessment of thyroid hormone system disruptors Ondřej Brózman (Brno, CZE) |
| 12.20 - 12.40 |
Selected and serious below-limit sources of chemical risk in the Czech Republic Otakar Jiří Mika (Praha, CZE) |
| 12.40 - 13.00 |
Behavioral outcomes of maternal stress and perinatal mirtazapine treatment in rat offspring Kristína Csatlósová (Bratislava, SVK) |
| 13.00 - 14.00 | Lunch and Exhibition |
14.00 - 14.20 |
Flash posters II |
| Chair: Kamil Musílek | |
| FP06 |
Pharmacological modulation of m-TOR in animal model of NAFLD/NASH Mahak Arora (Praha, CZE) |
| FP07 |
Cell growth on TiO2 nanotubes and ti flat substrates coated with metal oxides using atomic layer deposition Jana Báčová (Pardubice, CZE) |
| FP08 |
Novichok: basic knowledge of biochemical properties Vendula Hepnarová (Hradec Králové, CZE) |
| FP09 |
In vitro evaluation of BODIPY labeled bisquaternary amonium salts used as reactivators of inhibited acetlycholinesterase Eliška Prchalová (Hradec Králové, CZE) |
| FP10 |
In vitro model expressing acetylcholinesterase for evaluation of neurotoxicity and neuroprotection Lenka Pulkrábková (Hradec Králové, CZE) |
14.20 - 15.50 |
Session 5 - Toxins and Military Toxicology I |
| Chairs: Kamil Musílek, Michal Dubovický | |
| 14.20 - 14.50 keynote lecture |
Nerve agent inhibited cholinesterases can be efficiently reactivated by oximes with enhanced nucleophilicity Kamil Musílek (Hradec Králové, CZE) |
| 14.50 - 15.10 |
Oxidative status assessment of rats‘ brain injury following subacute exposure to K-oximes Vesna Jaćević (Belgrade, SRB) |
| 15.10 - 15.30 |
Antidepressants in treatment of maternal depression: risks and benefits Michal Dubovický (Bratislava, SVK) |
| 15.30 - 15.50 |
Comparison of topoisomerase 2 inhibitors dexrazoxane and XK469 for the prevention of anthracycline cardiotoxicity Anna Jirkovská (Hradec Králové, CZE) |
15.50 - 16.30 |
Posters with coffee and tea |
| 16.30 - 18.20 | Tourist programme, Start: in front of the Campus building |
| 19.00 - 00.00 | Gala dinner, Hotel U Královny Elišky, Malé náměstí 117, Hradec Králové |
Thursday 1 September 2022 |
|
08.30 - 10.30 |
Session 6 - Military Toxicology II |
| Chairs: Jiří Kassa, Tanos Celmar Costa Franca | |
| 08.30 - 08.50 |
Memantine and its combination with acetylcholinesterase inhibitors in pharmacological pretreatment of soman poisoning in mice Jiří Kassa (Hradec Králové, CZE) |
| 08.50 - 09.10 |
Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 Tanos Celmar Costa Franca (Rio de Janeiro, BRA) |
| 09.10 - 09.30 |
Reactivation of acetylcholinesterase inhibited by novichok agents – a computational study Tomáš Kučera (Hradec Králové, CZE) |
| 09.30 - 09.50 |
Benchmark dose approach in evaluation of in vivo AChE-reactivating efficacy of promising experimental oximes K203 and K027 Evica Antonijevic Miljakovic (Hradec Králové, CZE) |
| 09.50 - 10.10 |
In vitro decontamination efficacy of newly developed decontamination means on nerve agents Alžběta Dlabková (Hradec Králové, CZE) |
| 10.10 - 10.30 |
Chemical weapons from the perspective of international and national law Otakar Jiří Mika (Praha, CZE) |
10.30 - 10.50 |
Closing ceremony |
| Kamil Kuča | |
The programme is subject to change.