Hlavní témata

Structure and dynamics of cholinesterases and OP hydrolases
Interaction of cholinesterases with substrates, inhibitors and reactivators
Catalytical bioscavangers PON and PTE I - biotechnology and therapeutical aspects
Catalytical Bioscavangers - PON and PTE II - biological functions and related diseases
Reactivators of AChE, OP inhibitors - mechanism of toxicity, detection and analytical methods, diagnosis of exposure, detoxification and therapy; counter-terrorism strategies
Stoichiometric bioscavangers, biotechnology and therapeutical aspects (pre and post OP exposure)
Biological functions, development and non-cholinergic function of cholinesterases
Alzheimer's disease and diseases related to cholinesterases
Multi-target-directed ligands in Alzheimer's disease primarily targeting cholinesterases
Enzymes and proteins other than ChEs interacting with OP
3D section - structure and dynamics of α/β hydrolases and OP hydrolases, in silico methods for designing of modulator